Pathway analysis of GWAS

We recently completed a protein interaction-based pathway analysis combining GWAS data from more than 15,000 cases and 30,000 controls on behalf of the IMSGC. Here, statistical evidence of association was integrated with physical evidence of interaction to identify networks enriched in (even moderately) associated genes (IMSGC. Am J Hum Genet; 2013). Methods: Statistical genetics, graph theory, bioinformatics.