SPOKE explorer
The Scalable Precision-medicine Oriented Knowledge Engine (SPOKE) is a comprehensive biomedical knowledge graph connecting a wealth of information from basic molecular research, clinical insights, and many other databases
Welcome!
Welcome to the Baranzini Lab at UCSF where we explore the genetics and molecular mechanisms underlying complex diseases.
Our Latest Research in Genetics
Post-GWAS Pathway Analysis with Predicted Regulatory Scores
Our Latest Research in Data Science
Integrating biomedical research and electronic health records to create knowledge-based biologically meaningful machine-readable embeddings
Our Latest Research in Immunology
Recirculating Intestinal IgA-Producing Cells Regulate Neuroinflammation via IL-10.

The Baranzini Lab is interested in the genetics and molecular mechanisms underlying complex diseases.

In particular, we use a combination of wet and dry lab approaches to investigate the disease multiple sclerosis, an autoimmune disorder of the central nervous system. Work in our lab involves human genetics, immunology, molecular biology, bioinformatics and systems biology approaches.

We are also the creators of SPOKE, an open knowledge network that aims at integrating all publicly available biomedical information into a giant graph. Among other uses, SPOKE is being developed to aid in drug repurposing, precision medicine approaches, and molecular pharmacology.

Baranzini Lab