The Scalable Precision-medicine Oriented Knowledge Engine (SPOKE) is a comprehensive biomedical knowledge graph connecting a wealth of information from basic molecular research, clinical insights, and many other databases. The SPOKE Neighborhood Explorer tool allows anyone to interact with the knowledge graph in a hypothesis-driven manner and browse connections between genes, drugs, diseases and more. Recently, the SPOKE team added Sars-CoV-2 data from the Krogan Lab's work examining the viral proteins. Pre-loaded queries in the Neighborhood Explorer let you explore the viral-human protein interactions and how they are connected to other data elements within SPOKE. Their team is using SPOKE to inform candidates for drug repurposing, and also in combination with EHRs to identify pre-existing conditions that can put people at higher risk of hospitalization